If you’ve ever wondered why the symbol of health is a snake spiraling a staff (the Greek god Asclepius’s staff to be specific), it’s because in Ancient Greece they used small amounts of snake venom to treat serious illnesses
I imagine the long term solution to antibiotic resistance are engineered bacteriophages, either to directly attack the bacteria or to insert genes that make the bacteria susceptible to specific agents. Beyond not having to continuously develop new antibiotics or restrict treatment, these could also be much more targeted treatments with less harmful effects on a patient's microbiome. Of course scaling up to mass production on the level of say penicillin will take some time, but the same is true for new antibiotics.
"Researchers have developed", yeah. When I read such things, I always recall https://en.wikipedia.org/wiki/Epimerox - this thing promised wonders - very broad spectrum, very low toxicity - and, most importantly, it was targeting a conservative essential protein - so nearly zero resistance. And there were no updates for more than a decade.
Something developed in a lab is something we, most likely, will never see - and will never know why the thing didn't reach the 2nd stage (or the 1st).
I have struggled with various infections over the last 15 years. One of them, among the worst being h-pylori. Of all these infections, I've been forced, due to absence of healthcare and aversion to the medical industry in general, to treat myself across the board.
H Pylori is a very interesting subject, deeply misunderstood until a certain Australian hero brute forced through the arrogance of the day by infecting himself to prove ulcers weren't the product of psychosomatics.
Ending the rant there, I discovered through research that capsaicin (only one of the virtues of peppers) has a manifold effect upon various bacteria, notably pylori. Aside from encouraging the pylori to swim away from the capsaicin, it disrupts their biofilm behavior, and empirically, can drastically help with ulcers counter to expected problems with its spicy nature.
Adjacently, it can also encourage mucosal stimulation and protection.
I've found, co administered with mastic, oregano, NAC, and a few things presently inaccessible to the ol' cabbage.... Ahh, that's one... Cabbage juice! -- the infection can be reduced to sustainable levels without conventional antibiotics. Modern research is suggesting that h pylori, partly due to its ubiquity (50% of population +) and the ravages of antibiotics, it may be best to simply reduce it to manageable levels where the immune system and general well being keep it controlled.
There is also the wonder of fermented chilies which is good for many things, includes probiotics, improves most meals and really irritates assholes, which is righteous.
If you’ve ever wondered why the symbol of health is a snake spiraling a staff (the Greek god Asclepius’s staff to be specific), it’s because in Ancient Greece they used small amounts of snake venom to treat serious illnesses
We’ve come full circle
I imagine the long term solution to antibiotic resistance are engineered bacteriophages, either to directly attack the bacteria or to insert genes that make the bacteria susceptible to specific agents. Beyond not having to continuously develop new antibiotics or restrict treatment, these could also be much more targeted treatments with less harmful effects on a patient's microbiome. Of course scaling up to mass production on the level of say penicillin will take some time, but the same is true for new antibiotics.
"Researchers have developed", yeah. When I read such things, I always recall https://en.wikipedia.org/wiki/Epimerox - this thing promised wonders - very broad spectrum, very low toxicity - and, most importantly, it was targeting a conservative essential protein - so nearly zero resistance. And there were no updates for more than a decade.
Something developed in a lab is something we, most likely, will never see - and will never know why the thing didn't reach the 2nd stage (or the 1st).
https://archive.ph/1fAzz
Here's me hoping this is a hint that hot peppers kill a lot of things: resistant bacteria, cancers, inflamed cells, etc. since I love them so.
Nature is probably still one of the best drug discovery libraries we have
"keep in mind, so does a handgun"[0]
[0] https://xkcd.com/1217/
I have struggled with various infections over the last 15 years. One of them, among the worst being h-pylori. Of all these infections, I've been forced, due to absence of healthcare and aversion to the medical industry in general, to treat myself across the board.
H Pylori is a very interesting subject, deeply misunderstood until a certain Australian hero brute forced through the arrogance of the day by infecting himself to prove ulcers weren't the product of psychosomatics.
Ending the rant there, I discovered through research that capsaicin (only one of the virtues of peppers) has a manifold effect upon various bacteria, notably pylori. Aside from encouraging the pylori to swim away from the capsaicin, it disrupts their biofilm behavior, and empirically, can drastically help with ulcers counter to expected problems with its spicy nature.
Adjacently, it can also encourage mucosal stimulation and protection.
I've found, co administered with mastic, oregano, NAC, and a few things presently inaccessible to the ol' cabbage.... Ahh, that's one... Cabbage juice! -- the infection can be reduced to sustainable levels without conventional antibiotics. Modern research is suggesting that h pylori, partly due to its ubiquity (50% of population +) and the ravages of antibiotics, it may be best to simply reduce it to manageable levels where the immune system and general well being keep it controlled.
There is also the wonder of fermented chilies which is good for many things, includes probiotics, improves most meals and really irritates assholes, which is righteous.